Our day to day diet plays significant role in the inhibition of carcinogenic process which causes so many troubles in our health.Ginger for cancer prevention and control makes it to be selected as one of the most essential herbs in spice specious.The non-nutritive meal constituents release their ant carcinogenic effect through a number of mechanisms.Let’s see the basic systems how ginger for cancer causing chemicals could be applied.

Some of the mechanisms of ginger for cancer and  carcinogenic chemicals are:

1.   The character of their antioxidant property(That’s why ginger for cancer is the preferable way to show its significance)

2.    Direct indirect deactivation of  the carcinogens  and

3.    Increase on the tissue rate of protective enzymes in the body

Naturally toxic metabolites and chemicals of harmful drugs are detoxified by the body’s immunity system.Phytochemicals in spices such as turmeric, mustard and allium vegetables could act in many ways to confer their beneficial contribution.Recent researches made at the National Institute of Nutrition (NIN), Hyderabad points out that some of the spices and vegetables stimulate and enhance, specifically, the levels of glutathione-s-transferases (GST), enzyme groups particularly known as cellular detoxification enzymes.Hence,there is a figurative dependency between the induction of cellular detoxification enzymes and inhibition of carcinogenesis.

The significant power of Ginger for cancer

   Since ginger has the capacity to control chronic inflammation and arachidonic acid metabolism coupled with antioxidant property, studies were conducted to analyze the stimulation in drug metabolizing enzyme levels in laboratory rats, fed ginger through diet.Laboratory rats known as Wistar/NIN aged 2 to 2 and half months were classified into4 groups of six rats per group. For one month, ginger powder was fedat 0.5, 1 and 5% levels. The last group was maintained as control with no ginger feeding. Then, the food intake of the each rat was recorded every week throughout the study. The body weights of the animals were strictly recorded at the initial and final process of the experiment. After a month of feeding, the animals were sacrificed and lung, intestine, liver and kidney were collected, processed and amount of drug metabolizing measured.

At all ginger feeding level, stimulation of glutathione-s-transferases (GST) activity was seen in liver and lungs whereas in intestine and kidney, a crucial increase was observed at 1 and 5% level of ginger feeding. Though statistically non-significant,there was some increase in the activity of uridinediphospho–glucuronyltransferase (UDPGT) in liver, lung, kidney and intestine tissues. On the other hand, there was no significant difference in the levels of arylhydrocarbon hydroxylase(AHH) in treated and control groups of rats implying thereby that ginger feeding does not in any case enhance carcinogen metabolism. Major level of expected stimulation in liver quinonereductase (QR) was noted with 1 and5% ginger feeding compared to control. In lungs,on the other hand,the stimulation of GST due to ginger feeding in liver and lungs and to certain degree in intestine and kidney shows that ginger feeding can confer protection against the toxic effect of xenobiotics.The GST enzymes play a major role in the detoxification pathway and helpin the alteration of reactive chemicals to non-reactive polar compounds that can be excreted from the body.

Liver is the major organ of xenobiotic metabolism and transformation so that stimulatory effect of ginger feeding on liver and intestine enzyme levels is significant. Other tissues namely lungs and kidney also play key role in the detoxification and elimination of xenobiotics. The high level of GST in all these tissues further support the hypothesis that regular intake of ginger through diet can enhance the world of phase II detoxification enzymes.Reductase is another important phase II enzyme which participates in the antioxidative process. Improvement on the activity of quinonereductase shows that 5% ginger feeding can effectively counteract the oxidative damage in tissues of liver and lungs. However, major differences were not observed in kidney and intestine.Ginger for cancer cases in most of the researches has proved to result very good hope in rats and it is also applicable for human beings.

 

References

 

1. Langner, E., Greifenberg, S. and Gruenwald, J. Ginger: History and use.AdvTher 15: 25, 1998.

2. Govindarajan, V.S. Ginger: Chemistry, technology and quality evaluation (Part I). Crit Rev Food SciNutr 17: 1,

1982.

3. Mustafa, T., Srivastava, K.C. and Jensen, K.B. Drug Development Report (9) : Pharmacology of ginger, Zingiber officinale. J Drug Dev 6: 24, 1993.

4. Kiuchi, F., Shibuya, M. and Sankawa, V. Inhibitors of prostaglandin biosynthesis from ginger. Chem Pharm Bull

30: 754, 1993.

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