Recent medical reports in ginger and pregnancy suggests that ginger may be positive and effective alternative for the treatment of nausea and vomiting during pregnancy period. This result corroborates the findings of previous inconclusive analyses which depend on less extensive data on ginger and pregnancy. These types of similar studies were coming from Thailand in 2 studies, Australia in 2 studies and Denmark in 1 study and Canada in 1 study. If social or cultural similarities and differences among these populations are generalized to the universe of pregnant women, the whole world cannot be extrapolated from the current review. According to one recent score, the quality of the RCT’s retrieved was pretty nice to excellent, appropriate blinding of participants and investigators, effective way to generate the sequence of randomization, and the existence of effective control conditions. Nevertheless, a number of shortcomings have been noted for the effects of ginger and pregnancy.
Basic researches on the benefits of ginger and pregnancy
Among various trials, ginger with vitamin B6 is compared and both studies concluded that the spice was as effective as vitamin B6 in reducing nausea, related nausea cases and a number of vomiting episodes. However, the efficacy of vitamin B6 in vomiting, pregnancy and in nausea treatment is not compelling. In addition to this, a number of researches demonstrated that placebo treatment is essential in the relief of nausea. That’s why these comparative pregnancy studies should be viewed with caution and in one study 20% of women used conventional antiemetic during the trial period. Four clinical experiments compared the efficacy of ginger to a placebo and good methodological quality has been observed. During the study, women did not take other types of medical tablets and the compliance of the subjects was checked. With this in mind, the level of severity of pregnancy related symptoms was recorded more than once per day. In the study, a separate measurement of the nausea severity was obtained using two independent measurement scales.
The major problem in the process of carryover in pregnancy case is that crossover trials are the first possibilities of a carryover effect by the active substance formed in the second treatment. In this study, a severity score was applied to avoid a carryover effect of ginger and objectify the main symptoms of hyperemesis. All of the clinical trials show that, ginger was taken 3 to 4 times a day, independently of the occurrence of nausea and vomiting. Moreover, although the single dose of ginger changed in each study, the daily dose was approximately 1 g in 5 per 6 of reviewed studies. A prospective study consistently showed that there are no significant side effects occurred on pregnancy (from ginger and pregnancy perspective) outcomes which are consistent with the outcomes of the majority of animal studies. On the other hand, the short treatment periods and the small number of patients taking ginger in RCTs may not be sufficient to properly test the safety of ginger and pregnancy with respect to detailed outcomes.